AB147. 14. Colorectal post-operative infective complications worsen oncological outcomes—a meta-analysis
General Poster Session

AB147. 14. Colorectal post-operative infective complications worsen oncological outcomes—a meta-analysis

Jack Lawler, Katie Bailey, Úna Maguire, Michelle Choynowski, Alison Johnston, Michael Sugrue

Breast Centre North West, Letterkenny University Hospital, Co. Donegal, Ireland


Background: Optimising cancer outcomes is a complex interaction involving key strategies; prevention, early detection and optimal management. Negative outcomes need better understanding. A meta-analysis was undertaken to assess effects of postoperative infective surgical complications on oncological outcomes of colorectal cancer patients.

Methods: An ethically approved PROSPERO registered review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using databases PubMed and Scopus for studies that met eligibility criteria for articles between 2007 and 2017 reporting the effect of infective complications on oncological survival in colorectal cancer. Results were separated into infective complications, surgical site occurrence (SSO) superficial, deep and anastomotic leakage. Articles were then graded with methodological index for non-randomized studies (minors) grading (cut-off: 18/24). Data was analysed using RevMan5.

Results: Of the 5,027 articles reviewed, 72 articles met inclusion criteria. Infective complications occurred in 7.6% (0.8–54.7%) and had a significant negative effect on overall survival (HR: 1.39; 95% CI: 1.30–1.49), cancer specific survival (HR: 2.58; 95% CI: 2.15–3.10). Anastomotic leakage [incidence 6.43% (range, 2.52–45.6%)] showed a negative impact on disease-free survival (HR: 1.14; 95% CI: 1.09–1.20), overall survival (HR: 1.34; 95% CI: 1.28–1.39), cancer specific survival (HR: 1.43; 95% CI: 1.31–1.55), local recurrence (HR: 1.18; 95% CI: 1.06–1.32) and overall recurrence (HR: 1.46; 95% CI: 1.27–1.68).

Conclusions: This meta-analysis, one of the first to report oncological impact of post-operative infective complications identified a significant negative impact on both overall survival and cancer specific survival. Strategies that have been shown to reduce these complications need to be implemented as a priority to improve cancer survival.

Keywords: Colo-rectal cancer; oncological outcomes; meta-analysis; infective complications; anastomotic leakage


doi: 10.21037/map.2018.AB147


Cite this abstract as: Lawler J, Bailey K, Maguire �, Choynowski M, Johnston A, Sugrue M. Colorectal post-operative infective complications worsen oncological outcomes—a meta-analysis. Mesentery Peritoneum 2018;2:AB147. doi: 10.21037/map.2018.AB147