AB100. Body composition: association with operative and oncologic outcomes in the modern management of retroperitoneal sarcoma: results of a feasibility study
Session 7: General Session II

AB100. Body composition: association with operative and oncologic outcomes in the modern management of retroperitoneal sarcoma: results of a feasibility study

Tom McIntyre1, Jessie Andrea Elliott1, Noel Donlon2, Melissa Barnes1, Tara Connelly1, Una Hayden1, Naomi Hickey1, Amy Gillis1, Paul Ridgway1

1Department of Surgery, Tallaght University Hospital, Tallaght, Dublin, Ireland; 2Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St James’s Hospital, Dublin, Ireland


Background: Sarcopenia and obesity in cancer may confer negative outcomes, but their prevalence and impact on retroperitoneal sarcoma (RPS) therapy have not been systematically studied. Sarcopaenia and obesity measurements by computed tomography (CT) measurements at L3 may be confounded by the disease process itself. The aim of this study is to determine feasibility of demonstrating the prevalence of sarcopenia and visceral obesity in the management of RPS.

Methods: Consecutive sample patients undergoing treatment for RPS from our database were retrospectively studied. Total, subcutaneous and visceral fat areas (VFA), myosteatosis, skeletal muscle index (SMI) lean body mass and fat mass were determined at diagnosis by CT. Sarcopenia will be defined by CT at L3 as SMI <52.4 cm2/m2 for males and SMI <38.5 cm2/m2 for females, and visceral obesity as VFA >163.8 cm2 for men and >80.1 cm2 for women.

Results: Forty consecutive patients, 21 (52.5%) female, 56.7±15.1 years, were studied. The most common histologic types were leiomyosarcoma (8, 20.0%), dedifferentiated liposarcoma (7, 17.5%), well differentiated liposarcoma (7, 17.5%), myxoid liposarcoma (4, 10.0%). Mean ± SD body composition measures were: lean body mass, 50.4±12.0 kg; total fat mass, 27.2±8.6 kg; visceral fat area, 148.5±120.2 cm2; subcutaneous fat area, 222.2±120.4 cm2; myosteatosis, 8.9±7.3 cm2.

Conclusions: Assessment of body composition among patients with retroperitoneal sarcoma is feasible. Analysis to identify the prevalence and significance of sarcopenia and visceral obesity and its relationship to operative and oncologic outcomes is ongoing.

Keywords: Retroperitoneal; sarcoma; sarcopaenia


doi: 10.21037/map.2020.AB100
Cite this abstract as: McIntyre T, Elliott JA, Donlon N, Barnes M, Connelly T, Hayden U, Hickey N, Gillis A, Ridgway P. AB100. Body composition: association with operative and oncologic outcomes in the modern management of retroperitoneal sarcoma: results of a feasibility study. Mesentery Peritoneum 2020;4:AB100.