AB137. Predictive value of C-reactive protein/albumin ratio in major abdominal surgery
Session 10: General III

AB137. Predictive value of C-reactive protein/albumin ratio in major abdominal surgery

Noel Edward Donlon, Helen Mohan, Ross Free, Christina Fleming, Igor Soric, Ivan Ivanovski, Karl Schmidt, Ken Mealy

Department of Surgery, Wexford General Hospital, Wexford, Ireland


Background: Surgical site infection (SSI) is a major cause of morbidity, resulting in significant healthcare and economic implications. The ability to predict patients at high risk of SSI may enable targeted follow-up and management. This study sought to examine the relationship between the C-reactive protein (CRP)/albumin ratio in the prediction of SSI in patients undergoing emergency major abdominal surgery.

Methods: A retrospective study of all patients who underwent emergency major abdominal surgery in our institution over two years was performed. Patients were identified from a prospectively maintained database of SSI’s and cross referenced with hospital records. Patient demographics including age, gender, American Society of Anaesthesiology (ASA) grade, and wound classification (clean, clean/contaminated, contaminated, and dirty) were collated.

Results: CRP pre-operatively of greater than 5 was statistically significant in predicting an SSI (P<0.05). In addition, pre-operative serum Albumin of <32 was also significant in predicting a superficial site infection. Interestingly, preoperative CRP/Albumin ratio did not predict SSI, but post-operative CRP/Albumin ratio was predictive at both 24hr and 48 hr time points (P<0.05). Median length of stay in the SSI group was statistically significantly longer at 27.88 (range, 7–76) versus 18.32 (1–56) days (P<0.01).

Conclusions: Though CRP and Albumin have merit in isolation in preoperative identification of patients at risk of SSI, CRP/albumin ratio is a useful post-operatively adjunct in predicting SSI post-operatively at 24 and 48 hours post-operatively.

Keywords: C-reactive protein (CRP); albumin; surgical site infection (SSI); abdominal surgery


doi: 10.21037/map.2020.AB137
Cite this abstract as: Donlon NE, Mohan H, Free R, Fleming C, Soric I, Ivanovski I, Schmidt K, Mealy K. Predictive value of C-reactive protein/albumin ratio in major abdominal surgery. Mesentery Peritoneum 2020;4:AB137.