AB228. SOH21AS200. A rare case of incidental functioning neck paraganglioma in a multiple myeloma patient
Head & Neck Poster Session

AB228. SOH21AS200. A rare case of incidental functioning neck paraganglioma in a multiple myeloma patient

Waris Ali Shah, Zeeshan Razzaq, Hamid Mustafa, Sarah Lungley, Mohammed Daoud, Ian Brennan, Paul Ryan, Henry Paul Redmond

Department of Endocrine Surgery, Cork University Hospital, Cork, Ireland


Background: Paragangliomas are neuro-endocrine tumours originating from neural crest chromaffin cells. Majority (80–85%) are found in the medulla of adrenal glands referred to as pheochromocytomas. Catecholamine secreting neuro-endocrine tumours arising outside of adrenal medulla referred as paragangliomas constitute only 0.6% of all head and neck tumours. In this case study, we present a rare case of a sporadic and functioning neck paraganglioma in a multiple myeloma patient, which was an incidental pick up.

Methods: A 57-year lady awaiting stem cell transplant for multiple myeloma presented with chest pain. A CT-pulmonary angiogram (CT-PA) out ruled a pulmonary embolism but picked up an incidental finding of a 3.5 cm left neck/thoracic inlet mass. This mass was further characterized using ultrasound and biopsy, confirming a paraganglioma. Further imaging in form of metaiodobenzylguanidine (MIBG) and PET-CT scans confirmed no other focus of disease except the neck.

Results: The patient had preoperative alpha and beta blockade after discussion in the endocrine MDT followed by surgery via lower neck transverse incision. The surgery was un-eventful, and the patient was discharged home on her first post-operative day. Final histo-pathology confirmed a benign paraganglioma. Her genetic testing subsequently returned negative for MEN2/RET gene mutation.

Conclusions: This case report describes the first ever reported relationship in literature between neck paraganglioma and multiple myeloma. A multidisciplinary approach is recommended for these complex and rare cases with pre-operative blockade followed by surgery as the definitive cure.

Keywords: Paraganglioma; multiple myeloma; head and neck tumours


Acknowledgments

Funding: None.


Footnote

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/map-21-ab228). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


doi: 10.21037/map-21-ab228
Cite this abstract as: Shah WA, Razzaq Z, Mustafa H, Lungley S, Daoud M, Brennan I, Ryan P, Redmond HP. AB228. SOH21AS200. A rare case of incidental functioning neck paraganglioma in a multiple myeloma patient. Mesentery Peritoneum 2021;5:AB228.